Greater efficiency of polyherbal drug encapsulated biosynthesized chitosan nano-biopolymer on diabetes and its complications

What is it about?

This study developed a novel polyherbal anti-diabetic formulation using six medicinal plants, encapsulated in chitosan nanoparticles derived from prawn shells. The nanoparticles, synthesized via ionic gelation, showed high drug loading efficiency (85%) and were characterized using FT-IR, XRD, SEM, TEM, and EDAX. In diabetic rats, the encapsulated formulation significantly reduced blood glucose levels to near-normal and improved insulin levels, while also exhibiting hepatoprotective and antihyperlipidemic effects. Compared to the unencapsulated drug, the nanoparticle-based delivery offered superior efficacy. This research highlights a promising, natural alternative to synthetic anti-diabetic drugs, addressing issues like side effects and poor bioavailability. The use of chitosan nanoparticles enhances drug stability, targeted delivery, and sustained release, making it a valuable approach in diabetes management.

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Why is it important?

This research is important because it addresses the limitations of current diabetes treatments, including side effects and the low bioavailability of herbal medicines. By combining the synergistic effects of multiple antidiabetic herbs with a chitosan-based nanocarrier system, the study enhances therapeutic efficacy and stability. The nanoencapsulation ensures sustained and targeted delivery, leading to better glycemic control and mitigation of diabetic complications. Thus, this work offers a promising natural and safer alternative to synthetic anti-diabetic drugs, paving the way for future clinical applications of polyherbal nanoformulations.