Pt phosphor-, oxygen-rich complexes: One pot synthesis, characterization, molecular docking and antiproliferative study

What is it about?

This work includes the synthesis of a series of O- and P- rich platinum complexes by the reaction of Pt2 with tertiary phosphines (PPh3, dppm, dppe, dppp, dppf) and 3,4,5‑trimethoxybenzoic acid (HTMB) through a one-pot reaction. All complexes were characterized using FTIR, CHN, molar conductivity, 1H NMR, and 31P NMR. The characterization results proved that the TMB ligand in all complexes behaves as a monodentate through the deprotonated oxygen atom. The phosphine ligands were associated with the platinum center with chelating bidentate mode while PPh3 and dppm behaved as monodentate and bridging bidentate ligands, respectively. The PPh3-containing complex (trans-[Pt(TMB)2(PPh3)2]) was used to examine its anticancer activity against A2780, SW620, HT29, A172, C6, and HeLa cell lines. The results proved that the TGI value was 40.33 1.4, 18.05 0.8, 48.91 1.6, 44.43 2.8, 51.03 2.0, and 56.98 2.1 for A172, C6, HeLa, A2780, SW620 and HT29, respectively. TGI values were better than those reported for the reference compound 5FU. The molecular docking proves that trans-[Pt(TMB)2(PPh3)2] have pi-alkyl hydrophobic interaction, carbon-hydrogen bonding, electrostatic interaction, and pi-lone pair interaction with different amino acids.

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Why is it important?

This work aims to synthesize novel platinum complexes that contain the system P-MO. Furthermore, one of the complexes will be used as an anticancer against six different types of cancer cell lines and three normal cell lines in addition to checking its cytotoxicity compared with the 5FU drug.

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