What is it about?
This extensive meta-analysis aims to synthesize data from multiple case-control studies across diverse populations to clarify the association between the HER2 Ile655Val polymorphism and breast cancer risk. By integrating large-scale evidence, the analysis provides a more comprehensive and statistically robust understanding of this potential genetic risk factor, which could have implications for genetic screening and risk stratification in breast cancer.
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Why is it important?
Confirms the association between HER2 Ile655Val polymorphism and breast cancer, aiding in personalized risk evaluation. Highlights stronger risk association in Asian populations, pointing to the relevance of population-specific genetic studies. Encourages functional and translational research on HER2 pathways for improved therapeutic strategies.
Perspectives
This meta-analysis offers valuable insights into the genetic basis of breast cancer, emphasizing the importance of the HER2 Ile655Val polymorphism in modulating individual risk. The consistent association observed in specific subgroups, particularly in Asian populations, suggests potential gene-environment interactions or population-specific genetic backgrounds that influence susceptibility. These findings support the integration of genetic screening for HER2 variants in personalized risk prediction models, which may enhance early detection and preventive strategies. Moreover, understanding the functional impact of this polymorphism could advance the development of targeted therapies, especially for HER2-positive breast cancer patients. The study also underlines the necessity of conducting well-powered, ethnically diverse research to unravel the complex genetic landscape of breast cancer and inform future clinical guidelines.
Dr.Ramakrishnan Veerabathiran
Chettinad Health City
Read the Original
This page is a summary of: Association between HER2 (Ile655Val) polymorphism with risk of breast cancer: An extensive meta-analysis, Human Gene, May 2024, Elsevier,
DOI: 10.1016/j.humgen.2024.201280.
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