What is it about?
This study presents a meta-analysis investigating the association between the TMPRSS6 gene and the risk of anemia. TMPRSS6 plays a crucial role in iron homeostasis, and its genetic variants have been proposed as potential contributors to anemia susceptibility.
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Why is it important?
Anemia is a widespread global health problem affecting millions of individuals, with significant impacts on quality of life, productivity, and overall health. Understanding the genetic factors contributing to anemia is essential for improving diagnosis, prevention, and personalized treatment strategies.
Perspectives
This meta-analysis resolves inconsistencies among individual studies by providing high-level evidence that the TMPRSS6 rs855791 polymorphism is not significantly associated with anemia. The findings redirect attention toward other potential genetic factors contributing to anemia. By eliminating rs855791 as a major risk factor, this study refines the pool of genetic variants that should be considered in efforts to develop personalized diagnostic tools, risk assessments, and treatments for anemia.
Dr.Ramakrishnan Veerabathiran
Chettinad Health City
Read the Original
This page is a summary of: Lack of association between the TMPRSS6 gene polymorphism (rs855791) and anemia: a comprehensive meta-analysis, Hematology Transfusion and Cell Therapy, April 2025, Elsevier,
DOI: 10.1016/j.htct.2025.103737.
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