What is it about?
This study gives an integrated and systematic overview of the current state of knowledge with a clear idea of types of neural plasticity and the context-dependent role of epigenetic signature molecules.
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Why is it important?
- Neural plasticity, remodeling neural network is associated with learning and memory. - Neurons reorganize the strength and efficacy of synaptic transmission. - Epigenetic reprogramming is an established mechanism of neural plasticity. - Epigenetic signature proteins are the hallmark of epigenetic remodeling. - Natural bioactive compounds potentially modulate the epigenetic mechanism
Perspectives
Though the role of phytocompounds as epigenetic modulators has been discussed with redox regulation and neuronal dysfunction, their epigenetic link needs to be explored further in a context-dependent manner. This study has important implications for clinical and therapeutic interventions which will improve our mental health. In sum, neuroepigenetic research will be an extensive and incredible area of investigation to bridge the existing gap between basic neuroscience and clinical epigenetics.
Full Professor Ahmed R. G.
Division of Anatomy and Embryology, Zoology department, Faculty of Science, Beni-Suef University, Egypt.
Read the Original
This page is a summary of: Epigenetic signature in neural plasticity: the journey so far and journey ahead, Heliyon, December 2022, Elsevier,
DOI: 10.1016/j.heliyon.2022.e12292.
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