Genetic predisposition of MTHFR and TNFSF4 genes related to hypothyroidism

What is it about?

This paper presents a comprehensive meta-analysis examining the association between polymorphisms in the MTHFR and TNFSF4 genes and susceptibility to hypothyroidism. By systematically reviewing and pooling data from multiple genetic studies, the chapter evaluates the strength and consistency of these associations across diverse populations. It explores the potential biological mechanisms linking these gene variants to thyroid dysfunction, including effects on immune regulation, homocysteine metabolism, and inflammatory pathways. The work also identifies gaps in current research and highlights the need for further large-scale, multi-ethnic studies to validate these genetic markers as potential risk predictors for hypothyroidism.

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Photo by Europeana on Unsplash

Photo by Europeana on Unsplash

Why is it important?

Hypothyroidism is a common endocrine disorder with significant health consequences, yet its genetic risk factors remain poorly defined across populations. Understanding the role of MTHFR and TNFSF4 gene polymorphisms in predisposing individuals to hypothyroidism can improve early risk assessment, enhance disease prediction, and guide personalized prevention strategies. This paper is important because it consolidates current genetic evidence through meta-analysis, providing valuable insights that can inform future research, clinical screening approaches, and the development of precision medicine for hypothyroidism.

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