What is it about?
The association of p53 Pro72Arg, p73 G4C14-A4T14 (two linked polymorphism) and MDM2 T309G is unclear in oral cancer of Indian origin where tobacco chewing is widely practiced. This study was to evaluate the significance of these polymorphisms for the development of oral cancer.
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Why is it important?
High prevalence of p53 Pro72 [28.92%] in cancer patients is observed and is association with tobacco chewing as risk habit, while AT variant allele of p73 is less frequent in both the groups [<4%] and the MDM2 polymorphism is equally distributed in cases and control [25.98%] suggesting no involvement in oral cancer.
Perspectives
TP53 codon 72 Proline allele confers risk of developing oral cancer when tobacco chewing is practiced.
Dr ArunKumar Ganesan
Read the Original
This page is a summary of: Prevalence of p53 codon 72, p73 G4C14-A4T14 and MDM2 T309G polymorphisms and its association with the risk of oral cancer in South Indians, Gene Reports, June 2017, Elsevier,
DOI: 10.1016/j.genrep.2017.03.003.
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