What is it about?
Chemoresistance mediated by miRNAs in breast cancer is used to be validated in vitro, but how about in clinical samples? This article gathers up several breast cancer tissues, and depicts the probably chemoresistance-related miRNAs, providing the biomarkers to predict the chemotherapy responses. Finally, the detected miRNAs are helpful to develop the optimal chemotherapeutic choices for breast cancer patients.
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Why is it important?
We find that miR-222, miR-29a, miR-34a, miR-423, miR-140, miR-3178, miR-574, miR-6780b and miR-744 are all drug-resistance related miRNAs. This study highlights their roles in prediction of therapeutic responses and suggests that specific miRNAs could serve as valuable sources for biomarker detections and optimal chemotherapeutic choices for breast cancer patients.
Perspectives
I hope this article can provide illumination and insight for researchers who have been trying to develop chemoresistance related molecules and mechanisms.
Jin-Hai Tang
Nanjing Medical University
Read the Original
This page is a summary of: The role of miRNAs in drug resistance and prognosis of breast cancer formalin-fixed paraffin-embedded tissues, Gene, December 2016, Elsevier,
DOI: 10.1016/j.gene.2016.10.015.
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