What is it about?
The present study was aimed at designing and synthesizing a series of imine stilbene analogs and investigate its anti hypertrophic effects and regulatory mechanism in cardiac hypertrophy and apoptosis.
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Why is it important?
the low bio-avilalbility of resveratorol problem was also addressed by the application of green chemistry in synthesis of new Imine Stilbene analogues.
Perspectives
our data showed compound 3e has anti-hypertrophic activity as it could pharmacologically inhibit the potential targets that have regulatory mechanisms in cardiac hypertrophy. Undoubtedly, the initial studies have highlighted the therapeutic role of a resveratrol derivative which can impact the cross-talk between the integrated signaling networks controlling the entire myocardial growth process.
Dr. Raju Naini
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This page is a summary of: Imine stilbene analog ameliorate isoproterenol-induced cardiac hypertrophy and hydrogen peroxide-induced apoptosis, Free Radical Biology and Medicine, June 2020, Elsevier,
DOI: 10.1016/j.freeradbiomed.2020.04.014.
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