What is it about?

It is about understanding the sequence of events leading to renal cell apoptosis in the course of saturated fatty acid toxicity. Specifically, although endoplasmic reticulum (ER) stress and oxidative stress are two distinct pathways, the study elucidates that oxidants are responsible for ER stress induction and that antioxidants may prevent ER stress; however, although both pathways occur in renal cells exposed to saturated fatty acids, antioxidants do not help against fatty acid-induced ER stress in renal cells

Featured Image

Perspectives

evaluation of the clinical effects of certain antioxidants, unsaturated fatty acids and chemical chaperones on models of diabetes-induced microvascular damage.

Dr Elias N Katsoulieris

Read the Original

This page is a summary of: Lipotoxicity in renal proximal tubular cells: Relationship between endoplasmic reticulum stress and oxidative stress pathways, Free Radical Biology and Medicine, June 2010, Elsevier,
DOI: 10.1016/j.freeradbiomed.2010.03.021.
You can read the full text:

Read

Contributors

The following have contributed to this page