What is it about?
In this study, we report the qualitative–quantitative composition, antioxidant activity and cell viability-related properties of a defatted aqueous-acetone-soluble Pinus sibirica seed extract.
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Why is it important?
Pinus sibirica seeds are an abundant natural resource which are used for various medicinal purposes, yet pharmacognostic studies are rarely published, especially in English language publications. In this study, we investigated the chemistry of an aqueous-acetone- soluble extract and assessed its performance in a battery of antioxidant and cell viability assays. The extract predominantly contained phenolic compounds which would explain the antioxidant activities it demonstrated in antioxidant screening assays. The SH-SY5Y neuroblastoma cell culture data suggests that the extract can decrease the cell viability. However, the extract does not activate apoptosis, based on the analysis of p53 expression, but may have some necrotic effects, as indicated by the LDH and MTT analysis.
Perspectives
This information can be helpful when estimating the beneficial properties of Pinus sibirica extract or other plant extracts as valuable medicinal raw plant materials to be used for drug development.
Professor Alexander N. Shikov
Saint-Petersburg State Chemical Pharmaceutical University
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This page is a summary of: Chemical composition, antioxidative activity and cell viability effects of a Siberian pine (Pinus sibirica Du Tour) extract, Food Chemistry, February 2009, Elsevier,
DOI: 10.1016/j.foodchem.2008.07.008.
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