What is it about?

These data leads us to speculate that the function of the luminal epithelia (LE) differs from that of glandular epithelia (GE) even though both cell types are continuous in the endometrial monolayer. This is the first work to characterise LE, an essential cell-type for implantation by identifying mRNAs that are regulated at the non-receptive and the receptive secretory endometrium.

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Why is it important?

The LE differentially expressed mRNAs in the converse direction to that of GE, despite the glands being continuous with the luminal monolayer. These observations add to our understanding of the environment for blastocyst implantation. Our results introduce a new concept that endometrial morphology is not directly related to cellular function.

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This page is a summary of: In the secretory endometria of women, luminal epithelia exhibit gene and protein expressions that differ from those of glandular epithelia, Fertility and Sterility, July 2014, Elsevier,
DOI: 10.1016/j.fertnstert.2014.04.005.
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