What is it about?
Gene expression of the receptive endometrium was determined based on laser microdissected glands and stroma. One significant biological pathway, the cell cycle, was identified and signature protein staining patterns determined.
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Why is it important?
Microarrays demonstrated glands and stroma have distinct mRNA signatures, each dependent on the day of the cycle. We characterised two compartments of the receptive endometrium with a transcriptomic signature identifying regulation of only the cell cycle. IHC of cell cycle proteins identified a signature staining pattern of nuclear relocalisation of a group of cyclins of stromal cells which may be clinically applicable.
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This page is a summary of: Gene and protein expression signature of endometrial glandular and stromal compartments during the window of implantation, Fertility and Sterility, June 2012, Elsevier,
DOI: 10.1016/j.fertnstert.2012.03.007.
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