What is it about?
This manuscript describes a hypothesis of how the synthesis of S-adenosylmethionine is regulated in mammals. Combining in vitro and in vivo data obtained in different laboratories it is possible to produce a whole view of the different regulatory levels at which redox stress acts to modulate the production of this metabolite and, in turn of key methylation events such as epigenetic methylations.
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Why is it important?
It offers a whole view of the regulation of S-adenosylmethionine synthesis under normal and pathological conditions that concur with redox stress.
Perspectives
Writing this article helped to obtain an overall view of the importance and impact of redox stress in key metabolic events for any cell.
Dr María Ángeles Pajares
Centro de Investigaciones Biológicas Margarita Salas (CSIC)
Read the Original
This page is a summary of: How are mammalian methionine adenosyltransferases regulated in the liver? A focus on redox stress, FEBS Letters, May 2013, Wiley,
DOI: 10.1016/j.febslet.2013.04.034.
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