What is it about?
There is a lack of understanding of the processes that regulate differentiation in the prostate. Here we demonstrate that the novel prostate stem cell marker Dlk-1 is down-regulated by Notch signalling in differentiating prostate epithelia, and that mature prostate luminal cells co-express Notch-1 and its ligand Jagged1. Basal and epithelial stem cells were found to express the Notch-modulatory protein Dlk-1, as did a subpopulation of neuroendocrine cells, suggesting a hierarchical relationship.
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Why is it important?
We demonstrate that Notch regulates proliferation, differentiation and down-regulates the novel stem cell inhibitory protein Dlk-1 in the human normal prostate.
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This page is a summary of: Delta-Like 1 (Dlk-1), a Novel Marker of Prostate Basal and Candidate Epithelial Stem Cells, Is Downregulated by Notch Signalling in Intermediate/Transit Amplifying Cells of the Human Prostate, European Urology, December 2008, Elsevier,
DOI: 10.1016/j.eururo.2008.03.006.
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