What is it about?
Chronic lead exposure can generate pro-oxidative and pro-inflammatory conditions in the blood, related to high platelet activation and aggregation, altering cell functions. We studied ADP-stimulated aggregation and the oxidant/antioxidant system of platelets from chronically lead-exposed workers and non-exposed workers. Platelet aggregation was low in lead-exposed workers (62 vs. 97%), who had normal platelet counts and showed no clinical manifestations of hemostatic failure. ADP-activated platelets from lead-exposed workers failed to increase superoxide release (3.3 vs. 6.6 μmol/g protein), had low NADPH concentration (60 vs. 92 nmol/mg protein), high concentration of hydrogen peroxide (224 vs. 129 nmol/mg protein) and high plasma PGE2 concentration (287 vs. 79 pg/mL). Altogether, those conditions, on the one hand, could account for the low platelet aggregation and, on the other, indicate an adaptive mechanism for the oxidative status of platelets and antiaggregating molecules to prevent thrombotic problems in the pro-oxidant and pro-inflammatory environment of chronic lead exposure.
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Why is it important?
This work demonstrates how exposure to lead causes physiological readaptation in the exposed perosnal to reduce the effects of oxidative stress and inflammatory processes.
Perspectives
It is important to continue with the evaluation of the changes occurring in platelets and to determine their role in the anticoagulant response. Whether the prostaglandin response is sustained by the time of exposure to the metal, or is it a time and exposure level dependent response.
Ph.D. María Maldonado Vega
Hospital Regional de Alta Especialidad del Bajío
Read the Original
This page is a summary of: Adaptive changes in redox response and decreased platelet aggregation in lead-exposed workers, Environmental Toxicology and Pharmacology, June 2023, Elsevier,
DOI: 10.1016/j.etap.2023.104134.
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