What is it about?
Aim of the work: To determine sonographic features suggestive of amyloidosis in hemodialysis patients complaining of shoulder pain, and to study their relations to serum beta2-microglobulin (b2M).
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Why is it important?
As clinical symptoms of DRA are nonspecific, they may easily be misinterpreted as other joint diseases. Typical specific radiological amyloid bone cysts are a late event. Different studies observed that capsulosynovial swelling precedes the development of characteristic bone cysts. Ultrasonography (US) has been suggested as the modality of choice in evaluating DRA of the shoulder. Thickening of the supraspinatus tendon greater than 7 mm and thickening of the long head of the biceps tendon greater than 4 mm, both in the appropriate clinical setting, have correlated excellently with DRA of the shoulder.
Perspectives
Elevated serum b2M levels and sonographic features suggestive of dialysis-related amyloidosis (DRA) were found in all hemodialyzed patients complaining of shoulder pain either with or without clinical and/or radiological features suggestive of DRA. So, for diagnosis of DRA, sonographic features should correspond to the presence of clinically or radiologically evident b2M amyloid, and we should exclude other causes of non-amyloid changes.
Professor shereen refaat kamel
Minia University
Read the Original
This page is a summary of: Sonographic features suggestive of amyloidosis in hemodialysis patients: Relations to serum beta2-microglobulin, The Egyptian Rheumatologist, October 2014, Elsevier,
DOI: 10.1016/j.ejr.2014.03.004.
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