What is it about?
A specific thiosemicarbazone copper(II) complex has shown promise as a therapeutic agent by inducing apoptosis in gastric cancer cells through oxidative DNA damage and by targeting cancer stem cells to reduce their pluripotency. This complex, designated [Cu(L1)₂], generates reactive oxygen species (ROS), which damage DNA and trigger programmed cell death, while also demonstrating efficacy against cisplatin-resistant tumor cells.
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Why is it important?
Mechanism of Action describes: Oxidative Stress & DNA Damage, Apoptosis Induction, Cancer Stem Cell Targeting, reducing pluripotency.
Perspectives
Metals in medicine offer a unique opportunity to combat cancer
Dr ADORACION GOMEZ QUIROGA
Universidad Autonoma de Madrid
Read the Original
This page is a summary of: A select thiosemicarbazone copper(II) complex induces apoptosis in gastric cancer and targets cancer stem cells reducing pluripotency markers, European Journal of Medicinal Chemistry, December 2024, Elsevier,
DOI: 10.1016/j.ejmech.2024.116994.
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