What is it about?
Perfluoroalkylated methacrylates 7a–c bearing sulfinyl group within a straight-chain ester group, i.e. CH2=C(CH3)CO2CH2CH2S(O)–CH2CH2CF2(CF2CF2)nCF3 (n = 1–3) were prepared by two alternative synthetic sequences from 2-[(polyfluoroalkyl)sulfanyl]ethanols HOCH2CH2SCH2CH2CF2(CF2CF2)nCF3 (n = 1–3) in overall yields of 88–91%. Copolymers of 7a–c with diethylene glycol methacrylate (DEGMA) prepared in bulk under radical conditions display high transparency, increased water content and good oxygen permeability properties, which are advantageous for their application in ophthalmology and as prosthetic materials.
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Why is it important?
Perfluoroalkylated methacrylates 7a–c bearing sulfinyl group within a straight-chain ester group, i.e. CH2=C(CH3)CO2CH2CH2S(O)–CH2CH2CF2(CF2CF2)nCF3 (n = 1–3) were prepared by two alternative synthetic sequences from 2-[(polyfluoroalkyl)sulfanyl]ethanols HOCH2CH2SCH2CH2CF2(CF2CF2)nCF3 (n = 1–3) in overall yields of 88–91%. Copolymers of 7a–c with diethylene glycol methacrylate (DEGMA) prepared in bulk under radical conditions display high transparency, increased water content and good oxygen permeability properties, which are advantageous for their application in ophthalmology and as prosthetic materials.
Perspectives
Perfluoroalkylated methacrylates 7a–c bearing sulfinyl group within a straight-chain ester group, i.e. CH2=C(CH3)CO2CH2CH2S(O)–CH2CH2CF2(CF2CF2)nCF3 (n = 1–3) were prepared by two alternative synthetic sequences from 2-[(polyfluoroalkyl)sulfanyl]ethanols HOCH2CH2SCH2CH2CF2(CF2CF2)nCF3 (n = 1–3) in overall yields of 88–91%. Copolymers of 7a–c with diethylene glycol methacrylate (DEGMA) prepared in bulk under radical conditions display high transparency, increased water content and good oxygen permeability properties, which are advantageous for their application in ophthalmology and as prosthetic materials.
Dr Vladimír Církva
Institute of Chemical Process Fundamentals
Read the Original
This page is a summary of: New perfluoroalkylated amphiphilic methacrylates bearing sulfinyl group as monomers for biomedical applications: water content and oxygen permeability of their copolymers with DEGMA, European Journal of Medicinal Chemistry, November 2006, Elsevier,
DOI: 10.1016/j.ejmech.2006.06.003.
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