Epigenetic Pathways in Human Disease: The Impact of DNA Methylation on Stress-Related Pathogenesis and Current Challenges in Biomarker Development

What is it about?

A systematic review assessing clinical associations reported in relation to DNA methylation of HPA axis genes in adults.

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Why is it important?

We highlight current challenges in the field that will need to be addressed in order to develop clinically meaningful prognostic biomarkers, and to outline future research directions needed to create an evidence base that can inform public policy practice.