Keppra-induced pancytopenia

What is it about?

Pancytopenia is a rare side effect of levetiracetam (LEV) that is associated with severe morbidity that requires hospitalization. Here, we report a patient with a right temporoparietal tumor who underwent a temporal craniotomy with resection of the mass and was started on LEV for seizure prophylaxis per the neurosurgery local protocol. The patient developed LEV-induced pancytopenia, which was successfully managed by the discontinuation of this medication. Our report aims to increase awareness of this rare cause of pancytopenia among clinicians.

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Why is it important?

This topic is an important topic because Levetiracetam is a common medication that is used for treating a common condition. Early recognition of this adverse event can prevent the death of a patient who uses this medication.