Scientific competency questions as the basis for semantically enriched open pharmacological space development

Kamal Azzaoui, Edgar Jacoby, Stefan Senger, Emiliano Cuadrado Rodríguez, Mabel Loza, Barbara Zdrazil, Marta Pinto, Antony J. Williams, Victor de la Torre, Jordi Mestres, Manuel Pastor, Olivier Taboureau, Matthias Rarey, Christine Chichester, Steve Pettifer, Niklas Blomberg, Lee Harland, Bryn Williams-Jones, Gerhard F. Ecker
  • Drug Discovery Today, September 2013, Elsevier
  • DOI: 10.1016/j.drudis.2013.05.008

Scientific competency questions as the basis for semantically enriched open pharmacological space

What is it about?

In this review, we outline the scientific requirements identified by the Innovative Medicines Initiative (IMI) Open PHACTS consortium for the design of an open pharmacological space (OPS) information system. Typical scientific competency questions provided by the consortium members is analyzed based on the underlying data concepts and associations needed to answer the questions.

Why is it important?

In the design of a system for scientists interested in querying complex datasets to answer questions regarding pharmacology it is necessary to consider what some of those questions might be way ahead of time. This paper discusses the methodology of gathering that input as well as the resulting question set and should be of interest to anyone building similar systems in the future. Spend your time upfront gathering the appropriate user input rather than build it and they will come!

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http://dx.doi.org/10.1016/j.drudis.2013.05.008

The following have contributed to this page: Dr Antony John Williams and Dr Niklas U Blomberg