What is it about?
This work is about analysis of XRCC4 phosphorylation by DNA-PKcs. It shows which sites in XRCC4 are phosphorylated in a defined biochemical assay. Functional analysis of XRCC4 phosphorylation has been carried out as well.
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Why is it important?
Protein phosphorylation is one of key regulatory mechanisms of protein activity in cells. Here, a DNA repair protein has been analyzed.
Perspectives
MALDI Q-TOF MS/MS has been successfully applied in this work for identification of previously unknown phosphorylation sites in XRCC4.
Dr Marko Haramija
University of Rijeka
Read the Original
This page is a summary of: Identification of DNA-PKcs phosphorylation sites in XRCC4 and effects of mutations at these sites on DNA end joining in a cell-free system, DNA Repair, March 2004, Elsevier,
DOI: 10.1016/j.dnarep.2003.11.005.
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