What is it about?
In this work, we employed the bright Synchrotron X-ray fluorescence to track the penetration and accumulation of gold nanorods of different surface chemistry into the human skin layers. Furthermore, Synchrotron X-ray fluorescence provided us with valuable information regarding the interaction of the penetrated gold nanorods with the endogenous skin elements such as phosphorous and sulfur which may explain the mechanism of gold nanorods penetration through skin layers.
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Why is it important?
This work is considered the first in application of synchrotron X-ray fluorescence in tracking the penetration of gold nanorods through the Hunan skin layers. Moreover, the results support our previous findings concerning the gold nanorods-skin interface using transmission electron microscope and inductively coupled plasma-optical emission spectroscopy.
Perspectives
This works highlights the principle role of Synchrotron light in characterizing the interaction of the nano system with biological barrier. Synchrotron light provided fine X-ray maps regarding the distribution of gold and other skin elements in the skin and elaborated their possible interaction in skin.
Nouf Mahmoud
Al-Zaytoonah Private University of Jordan
Read the Original
This page is a summary of: Synchrotron-based X-ray fluorescence study of gold nanorods and skin elements distribution into excised human skin layers, Colloids and Surfaces B Biointerfaces, May 2018, Elsevier,
DOI: 10.1016/j.colsurfb.2018.02.021.
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