What is it about?
This study researched the relationship between iron-based nanozymes and ascorbic acid, i. e. Vitamin C. Two kinds of iron-based nanozymes Prussian blue nanoparticles (PBNPs) and iron oxide nanoparticles (IONPs) were used in this research. The results showed PBNPs can catalyze the oxidation of ascorbic acid by oxygen or H2O2. PBNPs can inhibit the anti-cancer ability of ascorbic acid. IONPs can promote the anti-cancer ability of ascorbic acid.
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Why is it important?
We study two kinds of iron-based nanoparticles Prussian blue nanoparticles (PBNPs) and Iron oxide nanoparticles (IONPs) and found that: 1. PBNPs can catalyze the oxidation of ascorbic acid (Vitamin C) by oxygen and H2O2, indicating PBNPs are ascorbic acid oxidase and peroxidase mimics. 2. PBNPs can inhibit the anti-cancer ability of ascorbic acid (Vitamin C), while IONPs can promote the anti-cancer ability. 3. The enzyme-like activities were studied by electron spin resonance (ESR) method.
Perspectives
I hope this article can provide illumination and insight for researchers who have been trying to study nanozymes and the anti-cancer mechanisms of ascorbic acid. Although iron is widely believed to promote the reactive oxygen species (ROS) generation, iron-based enzymes including HRP, peroxidase and catalase are anti-ROS enzymes. All these inspired us to study the relationship between iron-based nanozymes and ROS, taking ascorbic acid (Vitamin C) as the “bridge”.
Dr Wei Zhang
Jiangsu Province Hospital
Read the Original
This page is a summary of: Sparks fly between ascorbic acid and iron-based nanozymes: A study on Prussian blue nanoparticles, Colloids and Surfaces B Biointerfaces, March 2018, Elsevier,
DOI: 10.1016/j.colsurfb.2018.01.010.
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