What is it about?
This kind of nanomicelles were constructed by folic acid (FA)-decorated PEG-b-(PCL-g-PEI)-b-PCL triblock copolymers.
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Why is it important?
The obtained FA-PEG-b-(PCL-g-PEI)-b-PCL micelles was used for co-delivery of P-gp siRNA and DOX. The micelles have several advantages for siRNA and antitumor drug delivery, (1) increasing the solubility of the hydrophobic drug in the lipid “core” (2) efficient siRNA condensation by PEI (3) excellent stability in serum medium (4) tumor targeting via FR mediated cell uptake as well as passive targeting via EPR effect (5) fast release of DOX in lysosome (6) and enhanced sensitization of MCF-7/ADR cell line to DOX by siRNA therapy
Perspectives
Although preliminary, the results in this study demonstrated a tremendous potential of these multifunctional micelles for efficient targeted co-delivery of DOX and P-gp siRNA to reversing MDR in breast cancer. The PECL3 triblock copolymer poses great potential for synchronized delivery of hydrophobic drugs and multifunctional siRNA.
Dr Wei Zhang
Jiangsu Province Hospital
Some functional groups (such as alkyl or carboxyl groups) can be modified to the current triblock polymers, enabling them escape from the lysosomes and reach the cytoplasm and nucleus .
Dr Yang Wu
Jiangsu Cancer Hospital
Read the Original
This page is a summary of: Reversing of multidrug resistance breast cancer by co-delivery of P-gp siRNA and doxorubicin via folic acid-modified core-shell nanomicelles, Colloids and Surfaces B Biointerfaces, February 2016, Elsevier,
DOI: 10.1016/j.colsurfb.2015.11.041.
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