What is it about?
Nanoparticles, which are particles with diameters as small as few nanometers, have many applications in drug delivery. Because of their small size, these nanoparticles can easily permeate through membranes of biological cells to deliver their cargo of different drugs. Recently, preparation of these nanoparticles was found to be more efficient when perfromed inside microchannels instead of the regular bench top chemical techniques. In this study, we studied nanoparticle preparation inside microchannels to find the optimum combination of channel geometry and flow rates to prepare small nanoparticles with highest uniformity.
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Why is it important?
The results we obtained can help any researcher choose the right parameters in terms of microchannel dimension and flow conditions to produce nanoparticles of certain size and homogeneity. We believe our results are important to spread the use of microreactors for preparation of nanoparticles and espeed up the clinical translation of nanoparticles in many drug delivery applications including cancer therapy.
Perspectives
I enjoyed working on this study with colleagues from faculty of pharmacy at Assiut University and am very proud of the results we obtained.
Dr. Mohamed Abdelgawad
American University of Sharjah
Read the Original
This page is a summary of: Microchannel geometry vs flow parameters for controlling nanoprecipitation of polymeric nanoparticles, Colloids and Surfaces A Physicochemical and Engineering Aspects, February 2021, Elsevier,
DOI: 10.1016/j.colsurfa.2020.125774.
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