What is it about?
Highlights • Low IGF-I levels have not been consistently associated with human longevity. • Humans with more stable circulating IGF-I levels over time show better survival. • A low protein intake and low IGF-I in the very old may reduce life expectancy. • Reduced paracrine IGF-I-mediated effects may play an important role in longevity.
Featured Image
Why is it important?
This review shows that it is necessary not only to investigate systemic (endocrine) but also the paracrine effects of IGF-I to obtain an overall view about the role of IGF-I in the endocrinology of aging
Perspectives
In order to fully understand the effects of IGF-I on longevity in humans, nutritional intake, the trajectory of circulating IGF-I levels across life time and paracrine effects of IGF-I should be taken into account. The measurement of IGF-I receptor stimulating activity by the IGF-IR KIRA assay is a new promising tool than can provide new insights for the role of IGF-I during aging.
JAMJL Janssen
Erasmus Universiteit Rotterdam
Read the Original
This page is a summary of: IGF-I and the endocrinology of aging, Current Opinion in Endocrine and Metabolic Research, March 2019, Elsevier,
DOI: 10.1016/j.coemr.2018.11.001.
You can read the full text:
Contributors
The following have contributed to this page
