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Using a combination of in vitro and in vivo studies, Fusco et al. find that excess glucose impairs the self-renewal capacity of neural stem cells through a molecular circuit that involves the transcription factor CREB and Sirtuin 1. The authors suggest that this circuitry may link nutrient excess with neurodegeneration and brain aging.
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This page is a summary of: A CREB-Sirt1-Hes1 Circuitry Mediates Neural Stem Cell Response to Glucose Availability, Cell Reports, February 2016, Elsevier,
DOI: 10.1016/j.celrep.2015.12.092.
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