What is it about?
Our previous work identified Ser165 in alpha-tubulin as a target of PKCalpha in human breast cells. In this paper we show that Ser165 in alpha-tubulin is a "switch" that controls proliferation vs. motility and EMT phenotypes of human breast cells.
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Why is it important?
This work calls attention to a significant target for intervention in breast cancer metastasis.
Read the Original
This page is a summary of: Phosphorylation state of Ser165 in α-tubulin is a toggle switch that controls proliferating human breast tumors, Cellular Signalling, December 2018, Elsevier,
DOI: 10.1016/j.cellsig.2018.08.021.
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