What is it about?
SIRT1 (silent information regulator two protein) is a type III protein deacetylase that regulates a variety of important metabolic and physiologic processes including stress resistance, metabolism, apoptosis and energy balance. It reverses cholesterol transport and reduces risk for development of atherosclerosis and cardiovascular disease.
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Why is it important?
The review highlights the potential role of SIRT1 on cardiovascular biology and function.
Perspectives
Increasing evidence has shown that SIRT1 is closely related to cardiovascular diseases and regulates a number of key metabolic and physiological processes including senescence, stress resistance, energy metabolism and apoptosis. Thus, SIRT1 has a potential therapeutic value against cardiovascular diseases, though its exact protective mechanisms and whether it can be the target of relevant drugs is not clear.
Dr. Lina Ma
Read the Original
This page is a summary of: SIRT1: Role in cardiovascular biology, Clinica Chimica Acta, February 2015, Elsevier,
DOI: 10.1016/j.cca.2014.10.036.
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