What is it about?
Based on a series of tests carried out to determine the effects of Epigallocatechin-3-gallate, a green tea derivative, on an in vitro cell culture system that mimics the development of the corneal surface, we determined whether this compound could be useful for the treatment of alkali burns on the ocular surface
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Why is it important?
Our findings show that EGCG significantly improves the recovery of corneal chemical burns, reduces the inflammatory response after burns, and reduces corneal opacity in comparison with control animals. Treatment with EGCG improved clinical appearance of the cornea , that was associated to a controlled epithelial growth; epithelial morphology was similar to that observed in normal epithelium and contrasted with the hyperproliferative, desquamating epithelium observed in control burn wounds. EGCG reduced corneal, stromal and endothelial edema, and wound inflammation.
Perspectives
This work constitutes the first evidence for the use of EGCG in the acute phase of a corneal alkali burn, representing a possible novel alternative to improve patient outcomes as an add-on therapy. Next, experiments should be made to study the results in corneal wounds which are not treated immediately as in the series of experiments reported in this paper
Dr Federico Castro-Munozledo
Centro de Investigación y de Estudios Avanzados del IPN
Read the Original
This page is a summary of: (-)-Epigallocatechin-3-gallate, reduces corneal damage secondary from experimental grade II alkali burns in mice, Burns, March 2019, Elsevier,
DOI: 10.1016/j.burns.2018.08.021.
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