What is it about?
The noradrenergic and serotonergic system may have a role in modulation of absence seizures. We investigated whether the single injection of monoamine reuptake inhibitor clomipramine has an acute effect on spike-wave discharge (SWD) activity in Wistar Albino Glaxo/Rijswijk (WAG/Rij) rats. We injected a single dose of 20 or 50 mg/kg clomipramine intraperitoneally into WAG/Rij rats and measured the incidence and duration of SWD episodes for 4 hours after injection. The changes in SWDs were compared to the preceding 5 day average control level. The 20 mg/kg clomipramine significantly increased the incidence of SWDs in the first measured hour while the 50 mg/kg dose significantly increased the incidence and duration of SWDs in the whole measured 4-hour period.
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Why is it important?
Clomipramine, by acutely elevating synaptic monoamine levels, could exacerbate absence seizures.
Perspectives
Our results provide evidence that acute administration of clomipramine increase the occurrence of SWDs in WAG/Rij rats and this could be in relation of its noradrenaline and serotonin reuptake blocking effect.
Dr Zsolt Kovacs
Eötvös Loránd University
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This page is a summary of: Neonatal tricyclic antidepressant clomipramine treatment reduces the spike-wave discharge activity of the adult WAG/Rij rat, Brain Research Bulletin, November 2012, Elsevier,
DOI: 10.1016/j.brainresbull.2012.07.010.
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