What is it about?

Boron Neutron Capture Therapy (BNCT) is a type of radiotherapy where boron-containing compounds are preferentially uptaken by tumour cells and then the area is exposed to a low energy neutron beam (much less damaging than radiotherapy). This causes the boron, located in the cancer cells, to emit a radioactive alpha particle which destroys the cancer cells. Since the alpha particles can only travel about one cell's distance from the boron-containing cancer cells, surrounding normal tissue is unaffected. This paper describes the formulation and stability of nanoparticles, known as liposomes, containing the model boron-containing material, ortho carborane.

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Why is it important?

Formulating stable and effective boron-containing compounds is important in the development of Boron Neutron Capture Therapy for treating cancer.


A free download of the paper (postprint version) is available from the resources section (right-hand-side panel).

Dr James R Smith
University of Portsmouth

Read the Original

This page is a summary of: Liposome formulations of o-carborane for the boron neutron capture therapy of cancer, Biophysical Chemistry, February 2019, Elsevier,
DOI: 10.1016/j.bpc.2019.01.003.
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