What is it about?
Starting from triclosan led to the development of diaryl ureas. These compounds had nM activity in vitro and in vivo activity against P. Berghei. A pharmacophore was generated with 34 compounds that pulled out compoundsin the GSK library of antimalarials.
Why is it important?
A novel class of compounds was described with in vivo activity. The pharmacophore could be used to identify novel compounds for testing in future .
The following have contributed to this page: Dr Sean Ekins, Joel Freundlich, and Professor David A Fidock