What is it about?
Fabrication, improvements, biotechnological applications and future prospects.
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Why is it important?
Traditional chemical modification of proteins is via random multipoint attachment, resulting in a heterogeneous protein population with potential reduction in activity due to restriction of substrate access to the active site. Here we discuss chemistries where the modifier can be linked to a single specific amino acid in a protein molecule away from the active-site, thus enabling free access of the substrate.
Perspectives
Site-directed chemical modification can be used to immobilize enzymes on any support without compromising the activity.
Dr Khawar Sohail Siddiqui
University of New South Wales
Read the Original
This page is a summary of: Site-directed chemically-modified magnetic enzymes: fabrication, improvements, biotechnological applications and future prospects, Biotechnology Advances, May 2019, Elsevier,
DOI: 10.1016/j.biotechadv.2019.02.002.
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