What is it about?
Impedance can be used as a simple way of detecting biomarkers which are present in blood and indicate disease. We have made a number of impedance transducers as part of a polymer cartridge and modified them to detect biomarkers within a blood sample. This approach could be used for making a small handheld device that could be used for diagnosing different diseases in a low cost way.
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Why is it important?
We have shown a potentially low cost way of making a number of impedance transducers as part of a polymer cartridge. We also showed that antibody receptors can be easily attached to the impedance transducers once the cartridge has been made. These receptors bind biomarkers present in a blood sample and this is signalled by the impedance transducers to indicate disease. Having a number of impedance transducers allows you to look at different biomarkers for detection of different diseases or make repeated measurements of the same biomarker to provide a better test. Overall, we give an approach towards making a low cost and portable device for diagnosing disease.
Perspectives
I hope that this article will encourage others to think about using impedance as a low cost and relatively simple way of reliably diagnosing disease.
Professor Zulfiqur Ali
Teesside University
Read the Original
This page is a summary of: Impedimetric array in polymer microfluidic cartridge for low cost point-of-care diagnostics, Biosensors and Bioelectronics, January 2019, Elsevier,
DOI: 10.1016/j.bios.2018.12.054.
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