What is it about?
Despite of a diverse range of biological activities associated with chalcones and bis-chalcones, they are still neglected by the medicinal chemist for their possible α-amylase inhibitory activity. So, the current study is based on the evaluation of this class for the identification of new leads as α-amylase inhibitors.
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Why is it important?
Limited structure–activity relationship (SAR) was established by considering the effect of different groups attached to aryl rings on varying inhibitory activity. SMe group in chalcones and OMe group in bis-chalcones were found more influential on the activity than other groups.
Perspectives
However, in silico study predicted a number of interacting sites of the ligands (synthetic compounds) with the active site of α-amylase enzyme. This study has identified a number of lead compounds which can further explore in order to get a powerful inhibitor for α-amylase enzyme.
Dr. Sitansu Sekhar Nanda
Myongji University
Read the Original
This page is a summary of: Chalcones and bis -chalcones: As potential α -amylase inhibitors; synthesis, in vitro screening, and molecular modelling studies, Bioorganic Chemistry, September 2018, Elsevier,
DOI: 10.1016/j.bioorg.2018.05.003.
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