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Why is it important?
This article describes for the first time a magnet system for increased cell retention that can be readily scaled for use in man and importantly that the improved cell retention leads to reduced restenosis after arterial injury. This achievement represents a major step forward, as to date there has been no demonstration of the possibility to translate magnetic targeting or that cell retention leads to functional improvement.
Read the Original
This page is a summary of: Superparamagnetic iron oxide nanoparticle targeting of MSCs in vascular injury, Biomaterials, March 2013, Elsevier,
DOI: 10.1016/j.biomaterials.2012.11.040.
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Supplementary information
Supplementary video 1 - Experimental setup
This video features the ex vivo procedure followed to deliver and actuate magnetically loaded stem cells into an injured blood vessel.
Supplementary video 2 - In vivo test
This video shows the in vivo procedure to induce a vascular injury through balloon angioplasty, deliver magnetically loaded stem cells to the site and actuate them externally to maximize cell retaention into the injured vessel.
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