What is it about?
This work shows for the first time that aluminum modifies the responsiveness of neuronal-like cells to caffeine to trigger protective mechanisms. This epigenetic effect seems to involve adenosine A1 receptor antagonism beside that of The well-known A2A receptors.
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Why is it important?
The work implies that aluminum, although not accepted as a toxic metal, May interfere with intracellular mechanisms controlling neuronal defense responses.
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This page is a summary of: Dual blockade of the A1 and A2A adenosine receptor prevents amyloid beta toxicity in neuroblastoma cells exposed to aluminum chloride, The International Journal of Biochemistry & Cell Biology, September 2014, Elsevier,
DOI: 10.1016/j.biocel.2014.07.009.
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