What is it about?
Extracellular matrix stiffness regulates endocytic pathway.Our data showed that in corneal epithelium by regulating ECM stiffness through collagen crosslinking can regulate the uptake of molecules
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Why is it important?
This gives us a hint that in infectious keratitis ECM stiffness can modulate there entry of pathogens
Perspectives
In cornea,regulating ECM stiffness through collagen crosslinking is an FDA approved procedure to halt the progression of Keratoconus. We provide the first link that by collagen crosslinking we can control the pathogen entry as most of the pathogen enters through endocytic mechanism
Dr Amit chatterjee
Sankara Nethralaya
Read the Original
This page is a summary of: Probing the effect of matrix stiffness in endocytic signalling pathway of corneal epithelium, Biochemical and Biophysical Research Communications, April 2020, Elsevier,
DOI: 10.1016/j.bbrc.2020.02.067.
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