Inhibition of Mycobacterium tuberculosis topoisomerase I by m-AMSA, a eukaryotic type II topoisomerase poison

  • Adwait Anand Godbole, Wareed Ahmed, Rajeshwari Subray Bhat, Erin K. Bradley, Sean Ekins, Valakunja Nagaraja
  • Biochemical and Biophysical Research Communications, April 2014, Elsevier
  • DOI: 10.1016/j.bbrc.2014.03.029

A TB Topo I inhibitor

What is it about?

Identification of the first Tuberculosis Topisomerase I inhibitor.

Why is it important?

Likely the first paper to describe m-AMSA as a Topoisomerase I inhibitor. using computational and in vitro approaches.

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http://dx.doi.org/10.1016/j.bbrc.2014.03.029

The following have contributed to this page: Dr Sean Ekins