Distinction between phosphatidylcholine (PC)–specific phospholipase C (PC–PLC) and phosphatidylinositol (PI)–specific phospolipase C (PI–PLC) needs clarification

What is it about?

PI-PLC Phospholipase C acts on phosphotidylinositol (PI) to give IP3 and diacylglycerol (DAG) PC-PLC Phospholipase C acts on phosphatidylcholine (PC) to give phosphocholine and DAG DAGs produced from these enzyme actions are compositionally different

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Why is it important?

Second messenger DAGs produced from PI-PLC and PC-PLC have different composition can have impact on signal transduction mechanisms.