What is it about?
Examining the validity of a very common screening model for mania in rodents
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Why is it important?
Screening models are critical for drug development and the amph-induced hyperactivity is repeatedly used as one. However, our findings suggest that its validity in limited.
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This page is a summary of: Questioning the predictive validity of the amphetamine-induced hyperactivity model for screening mood stabilizing drugs, Behavioural Brain Research, April 2019, Elsevier,
DOI: 10.1016/j.bbr.2019.01.006.
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