Potentiation of morphine-induced CPP with concurrent use of amantadine and fluvoxamine

What is it about?

Neuopharmacology and Drug Addiction study by using Conditioned place prefernce

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Why is it important?

Our findings show that Amantadine also appears to work by increasing dopamine release from neuron. In conclusion, our results show that concurrent use of fluvoxamine and amantadine potentiate morphine-like effect on CPP through increasing dopaminergic transmission and this combination may simulate the rewarding effect of morphine and can be candidate for controlling the drug compulsive seeking in morphine dependent subjects.