What is it about?
Progesterone Receptor Membrane Component 1 (PGRMC1) is an unfortunately named protein that appears to play hitherto unrecognised roles in a variety of important disease. This review focuses on its role in cancer.
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Why is it important?
The crystal and NMR structures were recently solved, shedding new light onto the regulation of PGRMC1 functions by heme-mediated dimerisation and post-translational modification. PGRMC1 is emerging as a regulatory nexus hub protein, that acts like a fulcrum to cell differentiation, resulting in contrastingly different outcomes of cell plasticity.
Perspectives
PGRMC1 has to be one of the most interesting proteins around. It is involved in the aetiology of Alzheimer's disease, fertility disorders, and imposes gross metabolic changes on cancer cells. We know it is differently phosphorylated in cancers yet what it does precisely remains enigmatically out of sight. Th eprotein regulates vesicle trafficking and localisation of receptors to the cell surface, regulates cytochrome P450 enzymes that can detoxify therapeutic drugs, or alter steroid synthesis. It is somehow related to the Sigma 2 Receptor, which is a potent yet unidentified pharmacological target in cancer and neuro-degenerative diseases. Piqued your interest? Read the review. I hope you enjoy it. - Mike
Dr Michael A Cahill
Charles Sturt University
Read the Original
This page is a summary of: The emerging role of progesterone receptor membrane component 1 (PGRMC1) in cancer biology, Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, July 2016, Elsevier,
DOI: 10.1016/j.bbcan.2016.07.004.
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