What is it about?
Alternative splicing (AS) is emerging as an important control point of gene expression. AS allows a single gene to produce several mRNA with diverse biological functions. AS is deregulated during ageing, in fact aberrant AS has deep implications for age-related disease.
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Why is it important?
The regulation of alternative splicing is critical for numerous cellular functions in both pathological and physiological conditions, and deregulated alternative splicing is a key feature of common chronic diseases. Isoform choice is controlled by a battery of splicing regulatory proteins, which include the serine arginine rich (SRSF) proteins and the heterogeneous ribonucleoprotein (hnRNP) classes of genes. These important splicing regulators have been implicated in age-related disease, and in the ageing process itself. This review will outline the important contribution of splicing regulator proteins to ageing and age-related disease
Perspectives
Further investigation into how alternative splicing can be modified and in particular, how features of mRNA processing such as splicing factor expression or alternative splicing itself may be manipulated during ageing is now warranted to provide new insight into relationships between age, splicing regulation and disease
Eva Latorre
University of Exeter
Read the Original
This page is a summary of: Splicing regulatory factors, ageing and age-related disease, Ageing Research Reviews, July 2017, Elsevier,
DOI: 10.1016/j.arr.2017.04.004.
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