What is it about?

This review is aimed at the description of the molecular basis of glaucomatous damage in the high-tension glaucoma. It also allows to understand the difference between High tension and normal tension glaucoma

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Why is it important?

This paper provides a plausible explanation and is supported by a large bibliography on why glaucomatous damage originates in the anterior segment of the eye and arrives in the posterior segment leading to ganglion cell death.

Perspectives

This article focuses on the main target of high tension glaucoma: the trabecular meshwork setting the basis for a different way of seeing the pathogenesis of glaucoma

Dr Sergio C Sacca
IRCCS San Martino University Hospital, Department of Neuroscience and sense organs, San Martino Hospital, Ophthalmology Unit

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This page is a summary of: From DNA damage to functional changes of the trabecular meshwork in aging and glaucoma, Ageing Research Reviews, August 2016, Elsevier,
DOI: 10.1016/j.arr.2016.05.012.
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