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The methylenetetrahydrofolate reductase (MTHFR) gene plays a key role in the metabolism of folate and homocysteine (Hcy) and its mutations have been associated with high serum Hcy level. Elevated serum Hcy has been linked to impaired endothelial function and occlusive vascular disease. We studied the association among the different genotypes of all three MTHFR polymorphisms (C677T, A1298C, and G1793A) and the risk of early-onset vasculogenic erectile dysfunction (VED).

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The relationship between elevated plasma total homocysteine (tHcy) concentration (hyperhomocysteinemia) and vaso-occlusive disease has long been well documented. Hyperhomocysteinemia causes impotence and thus atherosclerosis. Individual variation in serum tHcy concentrations is related to several biological traits and is strongly influenced by dietary regimens, in particular the intake of vitamins such as folate, vitamin B6 and B12.

Dr Mohammad Reza Safarinejad
University of Medical Sceices

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This page is a summary of: Role of Methylenetetrahydrofolate Reductase Gene Polymorphisms (C677T, A1298C, and G1793A) in the Development of Early Onset Vasculogenic Erectile Dysfunction, Archives of Medical Research, August 2010, Elsevier, DOI: 10.1016/j.arcmed.2010.08.005.
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