What is it about?
In this study, first, we synthesized a new copper (II) complex and determined its toxic doses on NIH/3T3 normal fibroblast cells, SPC212 mesothelioma and DU145 prostate cancer cells. Then, we ascertained anti-proliferative, apoptotic, morphological, oxidative and endoplasmic reticulum (ER) stress-inducing effects of these newly synthesized compounds on DU145 prostate cancer cells.
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Why is it important?
Metal complexes are recently being investigated and combined with different moieties to discover new drugs since they have a couple of advantageous properties in terms of the number of coordination bounds they make, their flexible nature of geometries as well as their redox states.
Perspectives
As a result, the inhibitory effect of newly synthesized substance was superior to the chemicals from which it was synthesized. Its IC50s against DU145 were 37.0, 21.1 and 10.0 µM for 24, 48 and 72 h-treatments, respectively. Oxidative and ER stress increased after treatment. In microscopy, we observed apoptotic hallmarks like nuclear condensation, cellular shrinkage and membrane blebbings. In immunochemistry, increased Bax and decreased PCNA were apparent. Copper(II) complex with its relatively low IC50 can also be tested on other cancer and normal cell lines.
Sedat Kacar
Eskisehir Osmangazi Universitesi
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This page is a summary of: A Mononuclear Copper(II) Complex Containing Benzimidazole and Pyridyl Ligands: Synthesis, Characterization, and Antiproliferative Activity against Human Cancer Cells, Arabian Journal of Chemistry, August 2019, Elsevier,
DOI: 10.1016/j.arabjc.2019.08.002.
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